Mitochondrial Function and Insulin Resistance during Aging – A Mini-Review | Zendy

Esther Phielix | Zendy; Julia Szendroedi | Zendy; Michael Roden | Zendy

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Mitochondrial Function and Insulin Resistance during Aging – A Mini-Review

Author(s) -

Esther Phielix,

Julia Szendroedi,

Michael Roden

Publication year - 2010

Publication title -

gerontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.397

H-Index - 94

eISSN - 1423-0003

pISSN - 0304-324X

DOI - 10.1159/000317691

Subject(s) - insulin resistance , type 2 diabetes , endocrinology , medicine , insulin , mitochondrion , oxidative phosphorylation , biology , diabetes mellitus , lipid oxidation , genetics , biochemistry , antioxidant

Insulin resistance, i.e. impaired insulin sensitivity, and type 2 diabetes are more prevalent in elderly humans. Both conditions relate to lower aerobic performance and increased body fatness, which have been linked to reduced mitochondrial oxidative capacity. Thus, lower insulin sensitivity in the elderly could result from age-related diminished energy metabolism or from lifestyle-related abnormalities.

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