CYP26B1 Plays a Major Role in the Regulation of All-trans-Retinoic Acid Metabolism and Signaling in Human Aortic Smooth Muscle Cells | Zendy

Pauline Ocaya | Zendy; Ali Ateia Elmabsout | Zendy; Peder S. Olofsson | Zendy; Hans Törmä | Zendy; Andreas C. Gidlöf | Zendy; Allan Sirsjö | Zendy

Open Access

CYP26B1 Plays a Major Role in the Regulation of All-<i>trans</i>-Retinoic Acid Metabolism and Signaling in Human Aortic Smooth Muscle Cells

Author(s) -

Pauline Ocaya,

Ali Ateia Elmabsout,

Peder S. Olofsson,

Hans Törmä,

Andreas C. Gidlöf,

Allan Sirsjö

Publication year - 2010

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000317397

Subject(s) - retinoid , retinoic acid , gene silencing , microbiology and biotechnology , biology , small interfering rna , signal transduction , tretinoin , biochemistry , gene , rna

The cytochrome P450 enzymes of the CYP26 family are involved in the catabolism of the biologically active retinoid all-trans-retinoic acid (atRA). Since it is possible that an increased local CYP26 activity would reduce the effects of retinoids in vascular injury, we investigated the role of CYP26 in the regulation of atRA levels in human aortic smooth muscle cells (AOSMCs).

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