Norepinephrine and Serotonin Transporter Genes: Impact on Treatment Response in Depression | Zendy

Anna Baffa | Zendy; Christa Hohoff | Zendy; Bernhard T. Baune | Zendy; Carsten MüllerTidow | Zendy; Nicola Tidow | Zendy; Christine M. Freitag | Zendy; Peter Zwanzger | Zendy; Jürgen Deckert | Zendy; Volker Arolt | Zendy; Katharina Domschke | Zendy

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Norepinephrine and Serotonin Transporter Genes: Impact on Treatment Response in Depression

Author(s) -

Anna Baffa,

Christa Hohoff,

Bernhard T. Baune,

Carsten MüllerTidow,

Nicola Tidow,

Christine M. Freitag,

Peter Zwanzger,

Jürgen Deckert,

Volker Arolt,

Katharina Domschke

Publication year - 2010

Publication title -

neuropsychobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.71

H-Index - 83

eISSN - 1423-0224

pISSN - 0302-282X

DOI - 10.1159/000317285

Subject(s) - serotonin transporter , antidepressant , norepinephrine transporter , depression (economics) , medicine , 5 httlpr , psychology , haplotype , serotonin , endocrinology , major depressive disorder , allele , psychiatry , genetics , biology , gene , anxiety , receptor , amygdala , economics , macroeconomics

The norepinephrine transporter (NET) and serotonin transporter (5-HTT) genes constitute promising candidate genes in major depression. Seven polymorphisms in the promoter, intronic and exonic region of the NET gene, as well as serotonin-transporter-linked promoter region (5-HTTLPR) and 5-HTT rs25531 polymorphisms were analyzed with respect to antidepressant treatment response with particular attention to gender effects and subtypes of melancholic or anxious depression.

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