Mast Cell Infiltration Is Involved in Renal Interstitial Fibrosis in a Rat Model of Protein-Overload Nephropathy | Zendy

Ying Li | Zendy; Letiang Zhou | Zendy; Fuyou Liu | Zendy; Youming Peng | Zendy; Jun Li | Zendy; Lin Sun | Zendy; Shaobin Duan | Zendy; Guanghui Ling | Zendy; Xin Chen | Zendy; Wen-ling Jiang | Zendy; Yuncheng Xia | Zendy

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Mast Cell Infiltration Is Involved in Renal Interstitial Fibrosis in a Rat Model of Protein-Overload Nephropathy

Author(s) -

Ying Li,

Letiang Zhou,

Fuyou Liu,

Youming Peng,

Jun Li,

Lin Sun,

Shaobin Duan,

Guanghui Ling,

Xin Chen,

Wen-ling Jiang,

Yuncheng Xia

Publication year - 2010

Publication title -

kidney and blood pressure research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.806

H-Index - 51

eISSN - 1423-0143

pISSN - 1420-4096

DOI - 10.1159/000317102

Subject(s) - chymase , tryptase , fibrosis , mast cell , nephropathy , transforming growth factor , kidney , proteinuria , stem cell factor , medicine , endocrinology , pathology , immunohistochemistry , chemistry , biology , immunology , stem cell , microbiology and biotechnology , diabetes mellitus , haematopoiesis

The present study investigated the relationship between mast cells (MCs) and the protein expression of stem cell factor (SCF) and transforming growth factor-β1 (TGF-β1) in the regions of renal interstitial fibrosis with protein-overload nephropathy, in order to provide a good animal model to study the mechanism of renal fibrosis induced by proteinuria.

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