Open AccessLongitudinal Changes in the Corpus Callosum following Pediatric Traumatic Brain Injury
Author(s) -
Trevor C. Wu,
Elisabeth A. Wilde,
Erin D. Bigler,
Xiaoqi Li,
Tricia L. Merkley,
Ragini Yallampalli,
Stephen R. McCauley,
Kathleen P. Schnelle,
Ana C. Vásquez,
Zili D. Chu,
Gerri Hanten,
Jill V. Hunter,
Harvey S. Levin
Publication year - 2010
Publication title -
developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 82
eISSN - 1421-9859
pISSN - 0378-5866
DOI - 10.1159/000317058
Subject(s) - corpus callosum , fractional anisotropy , traumatic brain injury , splenium , diffusion mri , magnetic resonance imaging , white matter , medicine , atrophy , effective diffusion coefficient , psychology , pathology , radiology , psychiatry
Atrophy of the corpus callosum (CC) is a documented consequence of moderate-to-severe traumatic brain injury (TBI), which has been expressed as volume loss using quantitative magnetic resonance imaging (MRI). Other advanced imaging modalities such as diffusion tensor imaging (DTI) have also detected white matter microstructural alteration following TBI in the CC. The manner and degree to which macrostructural changes such as volume and microstructural changes develop over time following pediatric TBI, and their relation to a measure of processing speed is the focus of this longitudinal investigation. As such, DTI and volumetric changes in the CC in participants with TBI and a comparison group at approximately 3 and 18 months after injury as well as their relation to processing speed were determined.
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