Using a Pharmacokinetic Model to Relate an Individual’s Susceptibility to Alcohol Dependence to Genotypes | Zendy

Laura F. Mustavich | Zendy; Perry L. Miller | Zendy; Kenneth K. Kídd | Zendy; Hongyu Zhao | Zendy

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Using a Pharmacokinetic Model to Relate an Individual’s Susceptibility to Alcohol Dependence to Genotypes

Author(s) -

Laura F. Mustavich,

Perry L. Miller,

Kenneth K. Kídd,

Hongyu Zhao

Publication year - 2010

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000317056

Subject(s) - genotype , genetics , pharmacokinetics , biology , alcohol , psychology , computational biology , bioinformatics , gene , biochemistry

Population-based studies have successfully identified genes affecting common diseases, but have not provided a molecular mechanism. We describe an approach for alcohol dependence connecting a mechanistic model at the molecular level with disease risk at the population level, and investigate how this model implies statistical gene-gene interactions that affect disease risk.

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