Open AccessInduced Chromosome Deletion in a Williams-Beuren Syndrome Mouse Model Causes Cardiovascular Abnormalities
Author(s) -
Craig J. Goergen,
Honghua Li,
Uta Francke,
Charles A. Taylor
Publication year - 2010
Publication title -
journal of vascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 74
eISSN - 1423-0135
pISSN - 1018-1172
DOI - 10.1159/000316808
Subject(s) - elastin , adventitia , pulsatile flow , in vivo , blood pressure , aorta , microbiology and biotechnology , medicine , biology , endocrinology , chemistry , pathology , genetics
The Williams-Beuren syndrome (WBS) is a genetic disorder caused by a heterozygous ~1.5-Mb deletion. The aim of this study was to determine how the genetic changes in a Wbs mouse model alter Eln expression, blood pressure, vessel structure, and abdominal aortic wall dynamics in vivo.
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