Knockdown of Cyclophilin D Gene by RNAi Protects Rat from Ischemia/ Reperfusion-Induced Renal Injury | Zendy

Wei Hu | Zendy; Zhiqiang Chen | Zendy; Zhangqun Ye | Zendy; Ding Xia | Zendy; Zhongyu Xia | Zendy; Jiefeng Ma | Zendy; Min Zhu | Zendy; Gang Chen | Zendy

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Knockdown of Cyclophilin D Gene by RNAi Protects Rat from Ischemia/ Reperfusion-Induced Renal Injury

Author(s) -

Wei Hu,

Zhiqiang Chen,

Zhangqun Ye,

Ding Xia,

Zhongyu Xia,

Jiefeng Ma,

Min Zhu,

Gang Chen

Publication year - 2010

Publication title -

kidney and blood pressure research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.806

H-Index - 51

eISSN - 1423-0143

pISSN - 1420-4096

DOI - 10.1159/000316704

Subject(s) - gene knockdown , rna interference , mitochondrial permeability transition pore , kidney , reperfusion injury , biology , mitochondrion , voltage dependent anion channel , microbiology and biotechnology , chemistry , ischemia , programmed cell death , biochemistry , medicine , gene , apoptosis , rna , endocrinology , bacterial outer membrane , escherichia coli

Mitochondrial permeability transition has a critical role in ischemia/reperfusion (I/R)-induced kidney injury. It is thought that mitochondrial permeability transition occurs after the opening of the permeability transition pore, a channel which putatively consists of a voltage-dependent anion channel, adenine nucleotide translocator and cyclophilin D (CypD). Much evidence shows that CypD plays an important role in I/R-induced injury.

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