Role of Fosinopril and Valsartan on Klotho Gene Expression Induced by Angiotensin II in Rat Renal Tubular Epithelial Cells | Zendy

Qianying Zhou | Zendy; Song Lin | Zendy; Rong Tang | Zendy; Pouranan Veeraragoo | Zendy; Weilin Peng | Zendy; RenChin Wu | Zendy

Open Access

Role of Fosinopril and Valsartan on Klotho Gene Expression Induced by Angiotensin II in Rat Renal Tubular Epithelial Cells

Author(s) -

Qianying Zhou,

Song Lin,

Rong Tang,

Pouranan Veeraragoo,

Weilin Peng,

RenChin Wu

Publication year - 2010

Publication title -

kidney and blood pressure research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.806

H-Index - 51

eISSN - 1423-0143

pISSN - 1420-4096

DOI - 10.1159/000316703

Subject(s) - klotho , fosinopril , downregulation and upregulation , angiotensin ii , valsartan , blot , medicine , endocrinology , kidney , renin–angiotensin system , transforming growth factor , biology , chemistry , gene , angiotensin converting enzyme , receptor , biochemistry , blood pressure

Klotho gene, a new anti-aging gene, is mainly expressed in the kidney tubules. Several studies have found the relationship between klotho and emergence and development of renal diseases. This study set out to explore the role of fosinopril (Fos) and valsartan (Val) on klotho expression induced by angiotensin II (Ang II) in rat renal tubular epithelial cells (NRK-52E).

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