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The purpose of this study was: (1) to document the critical requirement of cystine for growth of human tumor cells in vitro, and (2) to determine the effect of the anticancer agent irinotecan on the cystine transporter x(c)(-) in head and neck FaDu xenografts.

Downregulation of Cystine Transporter x<sub>c</sub><sup>–</sup> by Irinotecan in Human Head and Neck Cancer FaDu Xenografts