Downregulation of Cystine Transporter xc– by Irinotecan in Human Head and Neck Cancer FaDu Xenografts | Zendy

Sreenivasulu Chintala | Zendy; Károly Tóth | Zendy; Ming-biao Yin | Zendy; Arup Bhattacharya | Zendy; Sylvia B. Smith | Zendy; Mohammad Shamsul Ola | Zendy; Shousong Cao | Zendy; Farukh A. Durrani | Zendy; Tanjima R. Zinia | Zendy; Rebecca Dean | Zendy; Harry K. Slocum | Zendy; Youcef M. Rustum | Zendy

Open Access

Downregulation of Cystine Transporter x<sub>c</sub><sup>–</sup> by Irinotecan in Human Head and Neck Cancer FaDu Xenografts

Author(s) -

Sreenivasulu Chintala,

Károly Tóth,

Ming-biao Yin,

Arup Bhattacharya,

Sylvia B. Smith,

Mohammad Shamsul Ola,

Shousong Cao,

Farukh A. Durrani,

Tanjima R. Zinia,

Rebecca Dean,

Harry K. Slocum,

Youcef M. Rustum

Publication year - 2010

Publication title -

chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.539

H-Index - 54

eISSN - 1421-9794

pISSN - 0009-3157

DOI - 10.1159/000316334

Subject(s) - irinotecan , chemistry , downregulation and upregulation , glutathione , western blot , microbiology and biotechnology , dna damage , cell growth , cystine , oxidative stress , cancer research , cancer , biology , biochemistry , medicine , dna , colorectal cancer , gene , cysteine , enzyme

The purpose of this study was: (1) to document the critical requirement of cystine for growth of human tumor cells in vitro, and (2) to determine the effect of the anticancer agent irinotecan on the cystine transporter x(c)(-) in head and neck FaDu xenografts.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research