Hypertonicity-induced Mitochondrial Membrane Permeability in Renal Medullary Interstitial Cells: Protective Role of Osmolytes | Zendy

Li Zhang | Zendy; Dong Chen | Zendy; Zhonghai Chen | Zendy; Gilbert Moeckel | Zendy

Open Access

Hypertonicity-induced Mitochondrial Membrane Permeability in Renal Medullary Interstitial Cells: Protective Role of Osmolytes

Author(s) -

Li Zhang,

Dong Chen,

Zhonghai Chen,

Gilbert Moeckel

Publication year - 2010

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000315095

Subject(s) - osmolyte , mitochondrial permeability transition pore , apoptosis , microbiology and biotechnology , cytochrome c , programmed cell death , chemistry , biophysics , membrane permeability , biology , biochemistry , membrane

Hyperosmotic stress causes cell death through activation of apoptotic pathways if the protective osmolyte response is impaired. In this study we attempt to elucidate the molecular mechanisms of hypertonicity-induced apoptosis and the effect of major organic osmolytes upon those.

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