Transcriptional Regulation of the Claudin-16 Gene by Mg2+Availability | Zendy

Edna Efrati | Zendy; Ayal Hirsch | Zendy; Orly Kladnitsky | Zendy; Julia Rozenfeld | Zendy; Marielle Kaplan | Zendy; Oren Zinder | Zendy; Israel Zelikovic | Zendy

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Transcriptional Regulation of the Claudin-16 Gene by Mg<sup>2+</sup>Availability

Author(s) -

Edna Efrati,

Ayal Hirsch,

Orly Kladnitsky,

Julia Rozenfeld,

Marielle Kaplan,

Oren Zinder,

Israel Zelikovic

Publication year - 2010

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000315090

Subject(s) - hypomagnesemia , reabsorption , transfection , medicine , hek 293 cells , hypermagnesemia , endocrinology , chemistry , messenger rna , claudin , receptor , kidney , microbiology and biotechnology , gene expression , biology , magnesium , gene , biochemistry , tight junction , organic chemistry

Renal tubular Mg(2+) reabsorption is mediated predominantly by the tight junction channel protein claudin-16 which is encoded by the gene CLDN16. Hypermagnesemia decreases, whereas hypomagnesemia increases Mg(2+) reabsorption. This study examines the role of claudin-16 in the adaptive response of the kidney to Mg(2+) availability.

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