Decreasing Txnip mRNA and Protein Levels in Pancreatic MIN6 Cells Reduces Reactive Oxygen Species and Restores Glucose Regulated Insulin Secretion | Zendy

Sweta Rani | Zendy; Jai Prakash Mehta | Zendy; Niall Barron | Zendy; Padraig Doolan | Zendy; Per Bendix Jeppesen | Zendy; Martin Clynes | Zendy; Lorraine O’Driscoll | Zendy

Open Access

Decreasing Txnip mRNA and Protein Levels in Pancreatic MIN6 Cells Reduces Reactive Oxygen Species and Restores Glucose Regulated Insulin Secretion

Author(s) -

Sweta Rani,

Jai Prakash Mehta,

Niall Barron,

Padraig Doolan,

Per Bendix Jeppesen,

Martin Clynes,

Lorraine O’Driscoll

Publication year - 2010

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000315086

Subject(s) - txnip , thioredoxin interacting protein , downregulation and upregulation , reactive oxygen species , small hairpin rna , blot , glucose homeostasis , insulin , endocrinology , medicine , diabetes mellitus , beta cell , biology , microbiology and biotechnology , intracellular , gene knockdown , apoptosis , cancer research , thioredoxin , insulin resistance , biochemistry , oxidative stress , islet , gene

Recently, thioredoxin-interacting protein (Txnip) expression has been implicated in a number of cellular events associated with diabetes, with increased Txnip levels associated with reduced glucose uptake into peripheral tissues, increased reactive oxygen species (ROS) in endothelial cells, beta cell glucotoxicity and apoptosis. The potential relevance of Txnip with regards to glucose-regulated insulin secretion (GSIS), a fundamentally important characteristic of beta cells and insulin-producing cells being considered as a possible cell therapy for diabetes, has not yet been investigated.

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