Electrophysiological Basis of the First Heart Beats | Zendy

Huamin Liang | Zendy; Marcel Halbach | Zendy; Tobias Hannes | Zendy; Bernd K. Fleischmann | Zendy; Ming Tang | Zendy; Heribert Schunkert | Zendy; Jürgen Hescheler | Zendy; Michael Reppel | Zendy

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Electrophysiological Basis of the First Heart Beats

Author(s) -

Huamin Liang,

Marcel Halbach,

Tobias Hannes,

Bernd K. Fleischmann,

Ming Tang,

Heribert Schunkert,

Jürgen Hescheler,

Michael Reppel

Publication year - 2010

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000315075

Subject(s) - electrophysiology , patch clamp , nifedipine , extracellular , verapamil , ion channel , membrane potential , cardiac electrophysiology , voltage dependent calcium channel , afterdepolarization , voltage clamp , channel blocker , chemistry , medicine , biophysics , calcium , biology , microbiology and biotechnology , receptor , repolarization

Earlier studies on cardiac pacemaker activity were inconclusive regarding the electrophysiological mechanism(s) of first electrical activity generation during cardiac development. We therefore aimed to investigate the role of ion channels in action potential (AP) formation and pacemaker activity during very early murine heart development (E8.5).

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