Panax Notogingseng Saponins Suppress RAGE/ MAPK Signaling and NF-kappaB Activation in Apolipoprotein-E-deficient Atherosclerosis-prone mice | Zendy

Xin Lin | Zendy; Yonggang Lu | Zendy; Tao Shen | Zendy; Xiuqing Huang | Zendy; Yong Man | Zendy; Shu Wang | Zendy; Jian Li | Zendy

Open Access

Panax Notogingseng Saponins Suppress RAGE/ MAPK Signaling and NF-kappaB Activation in Apolipoprotein-E-deficient Atherosclerosis-prone mice

Author(s) -

Xin Lin,

Yonggang Lu,

Tao Shen,

Xiuqing Huang,

Yong Man,

Shu Wang,

Jian Li

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000315061

Subject(s) - panax notoginseng , p38 mitogen activated protein kinases , chemistry , mapk/erk pathway , chemokine , rage (emotion) , apolipoprotein e , reactive oxygen species , endocrinology , medicine , pharmacology , signal transduction , inflammation , biology , biochemistry , pathology , alternative medicine , disease , neuroscience

Panax notoginseng saponins (PNS) extracted from the roots of panax notoginseng are free radical-scavenger, with an antioxidant property, capable of inhibiting expression of adhesion molecules and chemokines. This study was designed to test the effects of PNS administration in apolipoprotein (apo)-E-deficient mice on the activation of JNK, p38(MAPK), ERK1/2 and NF-κB, and the expression of RAGE, adhesion molecules and chemokines in the atherosclerotic lesions.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research