Myoepithelial Carcinoma: A Rare Neoplasm of the Breast | Zendy

Kuo-Chun Liao | Zendy; WenYing Lee | Zendy; Ming-Jenn Chen | Zendy

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Myoepithelial Carcinoma: A Rare Neoplasm of the Breast

Author(s) -

Kuo-Chun Liao,

WenYing Lee,

Ming-Jenn Chen

Publication year - 2010

Publication title -

breast care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.767

H-Index - 30

eISSN - 1661-3805

pISSN - 1661-3791

DOI - 10.1159/000313982

Subject(s) - myoepithelial cell , medicine , cytokeratin , atypia , nuclear atypia , myoepithelioma , pathology , surgical oncology , breast carcinoma , breast cancer , lymph node , cd117 , neoplasm , carcinoma , immunohistochemistry , cancer , oncology , cd34 , stem cell , biology , genetics

BACKGROUND: Malignant myoepitheliomas of the breast are extremely rare. There has been a limited number of published reports of myoepithelial carcinomas originating from the breast. CASE REPORT: We describe a malignant myoepithelioma of the breast in a 56-year-old woman. Histological examination showed polygonal epithelioid cells and spindle cells with moderate to marked nuclear atypia. Immunohistochemistry showed reactivity in the spindle cells for smooth muscle actin, cytokeratin (AE1/AE3), and p63, indicating a myoepithelial cell lineage of tumor cells. The patient underwent radical surgical excision of the lesion and axillary lymph node dissection. She demonstrated no evidence of recurrence over an 11-month follow-up. CONCLUSIONS: We suggest myoepithelial carcinomas of the breast be managed with appropriate surgical clearance. A multidisciplinary approach is usually required.

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