Progression of Chronic Kidney Disease: Adrenergic Genetic Influence on Glomerular Filtration Rate Decline in Hypertensive Nephrosclerosis | Zendy

Yuqing Chen | Zendy; Michael S. Lipkowitz | Zendy; Rany M. Salem | Zendy; Maple M. Fung | Zendy; Vibha Bhatnagar | Zendy; Manjula Mahata | Zendy; Caroline M. Nievergelt | Zendy; Fangwen Rao | Zendy; Sushil K. Mahata | Zendy; Nicholas J. Schork | Zendy; Andrew A. Hicks | Zendy; Donald W. Bowden | Zendy; Barry I. Freedman | Zendy; Victoria H. Brophy | Zendy; Daniel T. O’Connor | Zendy

Open Access

Progression of Chronic Kidney Disease: Adrenergic Genetic Influence on Glomerular Filtration Rate Decline in Hypertensive Nephrosclerosis

Author(s) -

Yuqing Chen,

Michael S. Lipkowitz,

Rany M. Salem,

Maple M. Fung,

Vibha Bhatnagar,

Manjula Mahata,

Caroline M. Nievergelt,

Fangwen Rao,

Sushil K. Mahata,

Nicholas J. Schork,

Andrew A. Hicks,

Donald W. Bowden,

Barry I. Freedman,

Victoria H. Brophy,

Daniel T. O’Connor

Publication year - 2010

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000313927

Subject(s) - medicine , nephrosclerosis , renal function , kidney disease , endocrinology , blood pressure , amlodipine , ramipril

African-Americans are likely to develop hypertension and hypertensive nephrosclerosis. This grave prognosis, coupled with familial aggregation of end-stage renal disease (ESRD) in Blacks, prompts a search for genetic risk factors for ESRD. Recent evidence implicates a crucial role for the sympathetic nervous system in progressive renal disease.

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