Prevention of Mast Cell Degranulation by Disodium Cromoglycate Delayed the Regression of Hypoxic Pulmonary Hypertension in Rats | Zendy

Hana Maxová | Zendy; Marianna Vasiľková | Zendy; J Novotná | Zendy; Olga Vajnerová | Zendy; Alena Baňsová | Zendy; M Vízek | Zendy; Jan Herget | Zendy

Open Access

Prevention of Mast Cell Degranulation by Disodium Cromoglycate Delayed the Regression of Hypoxic Pulmonary Hypertension in Rats

Author(s) -

Hana Maxová,

Marianna Vasiľková,

J Novotná,

Olga Vajnerová,

Alena Baňsová,

M Vízek,

Jan Herget

Publication year - 2010

Publication title -

respiration

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.264

H-Index - 81

eISSN - 1423-0356

pISSN - 0025-7931

DOI - 10.1159/000312403

Subject(s) - medicine , degranulation , hypoxia (environmental) , lung , pulmonary hypertension , ventricle , endocrinology , mast cell , right ventricular hypertrophy , anesthesia , immunology , receptor , chemistry , organic chemistry , oxygen

Pulmonary vascular remodeling induced by chronic hypoxia regresses after return to normoxia. This regression is associated with an increased amount of collagenase in pulmonary mast cells and increased collagenolytic and elastolytic activity in the lung tissue.

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