Increased Expression of DNA Methyltransferase-1 in Non-Neoplastic Epithelium Helps Predict Colorectal Neoplasia Risk in Ulcerative Colitis | Zendy

Shigehiko Fujii | Zendy; Yoshiki Katake | Zendy; Hiroyuki Tanaka | Zendy

Open Access

Increased Expression of DNA Methyltransferase-1 in Non-Neoplastic Epithelium Helps Predict Colorectal Neoplasia Risk in Ulcerative Colitis

Author(s) -

Shigehiko Fujii,

Yoshiki Katake,

Hiroyuki Tanaka

Publication year - 2010

Publication title -

digestion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.882

H-Index - 75

eISSN - 1421-9867

pISSN - 0012-2823

DOI - 10.1159/000311064

Subject(s) - dysplasia , colorectal cancer , ulcerative colitis , epithelium , carcinogenesis , medicine , pathology , immunohistochemistry , gastroenterology , cancer , disease

To clarify the possible significance of increased expression of DNA methyltransferase (DNMT)-1 in the tumorigenesis of colorectal neoplasia in ulcerative colitis (UC) and to clarify whether analysis of DNMT1 expression in non-neoplastic epithelium can contribute to the prediction of increased risk for UC-associated neoplasia.

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