Open AccessEarly Observations on Optic Neuritis and Uhthoff’s Sign
Author(s) -
J. Pearce
Publication year - 2010
Publication title -
european neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.573
H-Index - 77
eISSN - 1421-9913
pISSN - 0014-3022
DOI - 10.1159/000305926
Subject(s) - optic neuritis , sign (mathematics) , medicine , optic nerve , neuroscience , disease , psychology , optometry , multiple sclerosis , pathology , psychiatry , mathematical analysis , mathematics
For much of the 19th century, even after the discovery of the ophthalmoscope, the diagnostic clinical signs and the identity of primary optic nerve disease were confused and inaccurate. Amongst many contributions aimed at clarifying this muddle, those of Wilhelm Uhthoff and Edward Nettleship were of outstanding importance and are outlined here.
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