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Screening of drug safety is typically performed in diverse non-human healthy species with an intact repolarization reserve. Nevertheless, these drugs are later applied in diseased humans with a reduced repolarization reserve. It would be optimal to set up a preclinical screening tool to estimate the proarrhythmic potential of drugs in human cardiac tissue with a reduced repolarization reserve in vitro.

Human and Murine Embryonic Stem Cell-Derived Cardiomyocytes Serve Together as a Valuable Model for Drug Safety Screening