Human and Murine Embryonic Stem Cell-Derived Cardiomyocytes Serve Together as a Valuable Model for Drug Safety Screening | Zendy

Huamin Liang | Zendy; Matthias Matzkies | Zendy; Heribert Schunkert | Zendy; Ming Tang | Zendy; Hendrik Bonnemeier | Zendy; Jürgen Hescheler | Zendy; Michael Reppel | Zendy

Open Access

Human and Murine Embryonic Stem Cell-Derived Cardiomyocytes Serve Together as a Valuable Model for Drug Safety Screening

Author(s) -

Huamin Liang,

Matthias Matzkies,

Heribert Schunkert,

Ming Tang,

Hendrik Bonnemeier,

Jürgen Hescheler,

Michael Reppel

Publication year - 2010

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000303051

Subject(s) - verapamil , sotalol , quinidine , repolarization , pharmacology , drug , safety pharmacology , dofetilide , medicine , anti arrhythmia agents , embryonic stem cell , depolarization , electrophysiology , qt interval , cardiology , chemistry , biochemistry , calcium , atrial fibrillation , gene

Screening of drug safety is typically performed in diverse non-human healthy species with an intact repolarization reserve. Nevertheless, these drugs are later applied in diseased humans with a reduced repolarization reserve. It would be optimal to set up a preclinical screening tool to estimate the proarrhythmic potential of drugs in human cardiac tissue with a reduced repolarization reserve in vitro.

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