Downregulation of the Ornithine Decarboxylase/polyamine System Inhibits Angiotensin-induced Hypertrophy of Cardiomyocytes Through the NO/cGMP-dependent Protein Kinase Type-I Pathway | Zendy

Lin Yan | Zendy; Jicheng Liu | Zendy; Xiaojie Zhang | Zendy; Guangwei Li | Zendy; Lina Wang | Zendy; Yuhui Xi | Zendy; Hongzhu Li | Zendy; Yajun Zhao | Zendy; Changqing Xu | Zendy

Open Access

Downregulation of the Ornithine Decarboxylase/polyamine System Inhibits Angiotensin-induced Hypertrophy of Cardiomyocytes Through the NO/cGMP-dependent Protein Kinase Type-I Pathway

Author(s) -

Lin Yan,

Jicheng Liu,

Xiaojie Zhang,

Guangwei Li,

Lina Wang,

Yuhui Xi,

Hongzhu Li,

Yajun Zhao,

Changqing Xu

Publication year - 2010

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000303049

Subject(s) - medicine , endocrinology , cgmp dependent protein kinase , downregulation and upregulation , nitric oxide synthase , atrial natriuretic peptide , nitric oxide , angiotensin ii , ornithine decarboxylase , chemistry , enos , protein kinase a , muscle hypertrophy , polyamine , soluble guanylyl cyclase , kinase , biology , biochemistry , cyclin dependent kinase 2 , enzyme , guanylate cyclase , gene , blood pressure

Polyamines and nitric oxide (NO) have been involved in the pathogenesis of cardiac hypertrophy. NO can regulate cardiac ion channels by direct actions on G-proteins and adenyl cyclase. The present study was undertaken to elucidate the molecular mechanism of interactions with polyamines and NO in cardiac hypertrophy.

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