Multiple Integrations of Human T-Lymphotropic Virus Type 1 Proviruses in the Engrafted Cells from the Asymptomatic Carriers in NOD/SCID/γcnull Mice | Zendy

Ikuo Yamamoto | Zendy; Ichiro Takajo | Zendy; Kazumi Umeki | Zendy; Kazuhiro Morishita | Zendy; Kinta Hatakeyama | Zendy; Hiroaki Kataoka | Zendy; Hajime Nomura | Zendy; Akihiko Okayama | Zendy

Open Access

Multiple Integrations of Human T-Lymphotropic Virus Type 1 Proviruses in the Engrafted Cells from the Asymptomatic Carriers in NOD/SCID/γc<sup>null</sup> Mice

Author(s) -

Ikuo Yamamoto,

Ichiro Takajo,

Kazumi Umeki,

Kazuhiro Morishita,

Kinta Hatakeyama,

Hiroaki Kataoka,

Hajime Nomura,

Akihiko Okayama

Publication year - 2010

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000302760

Subject(s) - virology , human t lymphotropic virus , biology , nod , virus , antigen , asymptomatic carrier , peripheral blood mononuclear cell , in situ hybridization , microbiology and biotechnology , asymptomatic , immunology , messenger rna , medicine , in vitro , pathology , diabetes mellitus , gene , biochemistry , neuroscience , myelopathy , spinal cord , endocrinology

Successful engraftment of human T-lymphotropic virus type 1 (HTLV-1)-infected cells and a marked increase of proviral DNA loads (PVLs) in non-obese diabetic/severe combined immunodeficient (NOD/SCID)/gammac(null) (NOG) mice have been reported. Whether the increased PVL in transplanted mice is due to the new infection of HTLV-1 was examined.

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