Association of a Genetic Variant in the ALOX5AP with Higher Risk of Ischemic Stroke: A Case-Control, Meta-Analysis and Functional Study | Zendy

Sophie DominguesMontanari | Zendy; Israel FernándezCadenas | Zendy; Alberto del Río-Espínola | Zendy; Natália Corbeto | Zendy; Tiago Krug | Zendy; Helena Manso | Zendy; Liliana Gouveia | Zendy; João Sobral | Zendy; Maite Mendióroz | Zendy; Jessica FernándezMorales | Zendy; José ÁlvarezSabín | Zendy; Marc Ribó | Zendy; Marta Rubiera | Zendy; Vı́ctor Obach | Zendy; Joan MartíFàbregas | Zendy; Marimar Freijó | Zendy; Joaquı́n Serena | Zendy; José M. Ferro | Zendy; Astrid M. Vicente | Zendy; Sofia A. Oliveira | Zendy; Joan Montaner | Zendy

Open Access

Association of a Genetic Variant in the <i>ALOX5AP</i> with Higher Risk of Ischemic Stroke: A Case-Control, Meta-Analysis and Functional Study

Author(s) -

Sophie DominguesMontanari,

Israel FernándezCadenas,

Alberto del Río-Espínola,

Natália Corbeto,

Tiago Krug,

Helena Manso,

Liliana Gouveia,

João Sobral,

Maite Mendióroz,

Jessica FernándezMorales,

José ÁlvarezSabín,

Marc Ribó,

Marta Rubiera,

Vı́ctor Obach,

Joan MartíFàbregas,

Marimar Freijó,

Joaquı́n Serena,

José M. Ferro,

Astrid M. Vicente,

Sofia A. Oliveira,

Joan Montaner

Publication year - 2010

Publication title -

cerebrovascular diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.221

H-Index - 104

eISSN - 1421-9786

pISSN - 1015-9770

DOI - 10.1159/000302738

Subject(s) - single nucleotide polymorphism , medicine , snp , genetic association , genome wide association study , genetics , allele , gene , genotype , biology

Variants in the 5-lipoxygenase-activating protein (ALOX5AP) and phosphodiesterase 4D (PDE4D) genes have first been associated with ischemic stroke (IS) through whole-genome linkage screens. However, association studies obtained conflicting results. We aimed to investigate the contribution of selected single nucleotide polymorphisms (SNPs) in these genes for the first time in a large Iberian population.

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