Delta-Centralization Fails to Control for Population Stratification in Genetic Association Studies | Zendy

Tony Dadd | Zendy; Cathryn M. Lewis | Zendy; Michael E. Weale | Zendy

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Delta-Centralization Fails to Control for Population Stratification in Genetic Association Studies

Author(s) -

Tony Dadd,

Cathryn M. Lewis,

Michael E. Weale

Publication year - 2010

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000302720

Subject(s) - population stratification , statistic , population , locus (genetics) , matching (statistics) , test statistic , allele , allele frequency , null hypothesis , ancestry informative marker , biology , genetics , statistics , computer science , econometrics , statistical hypothesis testing , mathematics , single nucleotide polymorphism , genotype , demography , gene , sociology

To investigate the validity of simulations and assumptions used to underpin the delta-centralization (DC) method for correcting for population stratification in genetic association studies; to assess the effectiveness of DC compared to genomic control (GC) under valid simulation conditions; and to highlight other studies employing similarly flawed simulations.

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