Proliferation but Not Migration Is Associated with Blood Vessels during Development of the Rostral Migratory Stream | Zendy

Kai Nie | Zendy; Zoltán Molnár | Zendy; Francis G. Szele | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Proliferation but Not Migration Is Associated with Blood Vessels during Development of the Rostral Migratory Stream

Author(s) -

Kai Nie,

Zoltán Molnár,

Francis G. Szele

Publication year - 2010

Publication title -

developmental neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 82

eISSN - 1421-9859

pISSN - 0378-5866

DOI - 10.1159/000301135

Subject(s) - neuroblast , rostral migratory stream , biology , embryonic stem cell , microbiology and biotechnology , anatomy , neuroscience , cortex (anatomy) , embryogenesis , neural stem cell , neurogenesis , stem cell , embryo , subventricular zone , genetics , gene

Blood vessels play a critical role in regulating neural stem cell proliferation and migration. We show here that blood vessels became progressively aligned in the direction of the rostral migratory stream (RMS) from embryonic day 14 to postnatal day 4. Dividing cells revealed by phosphohistone H3+ immunoreactivity were statistically closer to isolectin B4+ blood vessels than predicted by chance in the emerging RMS. The close proximity of blood vessels and H3+ cells was consistent regardless of the age of the RMS and was strikingly similar to the embryonic cerebral cortex. In contrast to the adult RMS, we found no evidence for preferential juxtaposition of migratory doublecortin-positive neuroblasts and vasculature in the neonatal RMS. Our work provides an important framework for understanding the precise mechanism behind regulation of proliferation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research