Hydrogen Sulfide Regulates Homocysteine-Mediated Glomerulosclerosis
Author(s) -
Utpal Sen,
Charu Munjal,
Natia Qipshidze,
Oluwasegun A Abe,
Riyad Gargoum,
Suresh C. Tyagi
Publication year - 2010
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000296717
Subject(s) - cystathionine beta synthase , endocrinology , medicine , downregulation and upregulation , glomerulosclerosis , cystathionine gamma lyase , nad(p)h oxidase , kidney , sodium hydrosulfide , renal function , chemistry , microbiology and biotechnology , biochemistry , biology , oxidative stress , nadph oxidase , hydrogen sulfide , enzyme , proteinuria , gene , sulfur , organic chemistry , cysteine
In this study we tested the hypothesis that H(2)S regulates collagen deposition, matrix metalloproteinases (MMP) and inflammatory molecules during hyperhomocysteinemia (HHcy) resulting in attenuation of glomerulosclerosis and improved renal function.
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