Fetal Circulatory Endothelin-1,2 in the Midtrimester | Zendy

Eyed Schiff | Zendy; Y. Zalel | Zendy; Steven A. Friedman | Zendy; Eliezer Shalev | Zendy

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Fetal Circulatory Endothelin-1,2 in the Midtrimester

Author(s) -

Eyed Schiff,

Y. Zalel,

Steven A. Friedman,

Eliezer Shalev

Publication year - 1993

Publication title -

gynecologic and obstetric investigation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.631

H-Index - 63

eISSN - 1423-002X

pISSN - 0378-7346

DOI - 10.1159/000292696

Subject(s) - fetus , endothelin 1 , circulatory system , in utero , radioimmunoassay , umbilical vein , fetal circulation , medicine , endothelin receptor , endothelins , endocrinology , placental circulation , gestational age , hemodynamics , pregnancy , placenta , biology , biochemistry , genetics , receptor , in vitro

Umbilical-vein blood from eight fetuses who underwent cordocentesis for rapid karyotyping at 19-22 gestational weeks was tested for immunoreactive endothelin-1,2 by means of radioimmunoassay. Endothelin was detected in the serum of all but one of these fetuses. Levels of endothelin-1,2 ranged from 8.5 to 19.2 fmol/ml (mean 13.4 fmol/ml). We speculate that endothelin in the fetoplacental circulation may play a role in the regulation of fetal hemodynamics in utero.

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