Constitutive Suppression of PRL-3 Inhibits Invasion and Proliferation of Gastric Cancer Cell in vitro and in vivo | Zendy

Yasuko Matsukawa | Zendy; Shuho Semba | Zendy; Hirotaka Kato | Zendy; Yuichiro Koma | Zendy; Kazuyoshi Yanagihara | Zendy; Hiroshi Yokozaki | Zendy

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Constitutive Suppression of PRL-3 Inhibits Invasion and Proliferation of Gastric Cancer Cell in vitro and in vivo

Author(s) -

Yasuko Matsukawa,

Shuho Semba,

Hirotaka Kato,

Yuichiro Koma,

Kazuyoshi Yanagihara,

Hiroshi Yokozaki

Publication year - 2010

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000292649

Subject(s) - in vivo , gene knockdown , metastasis , biology , in vitro , cancer , cancer research , cancer cell , transfection , cell culture , cell growth , spleen , small interfering rna , endocrinology , medicine , immunology , biochemistry , microbiology and biotechnology , genetics

Overexpression of phosphatase of regenerating liver-3 (PRL-3) has been implicated in tumor progression and metastasis of gastric carcinoma. Here we examined what alterations occur in the phenotype of gastric cancer cells in vitro and in vivo when PRL-3 expression is knocked down.

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