Open AccessAntiproliferative Effects of Octadecyloxyethyl 9-[2-(Phosphonomethoxy)Ethyl]Guanine against Me-180 Human Cervical Cancer Cells in vitro and in vivo
Author(s) -
Nadejda Valiaeva,
Julissa Trahan,
Kathy A. Aldern,
James R. Beadle,
Karl Y. Hostetler
Publication year - 2010
Publication title -
chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.539
H-Index - 54
eISSN - 1421-9794
pISSN - 0009-3157
DOI - 10.1159/000292582
Subject(s) - in vivo , hela , ode , guanine , in vitro , cidofovir , cervical cancer , prodrug , cancer , microbiology and biotechnology , pharmacology , medicine , biology , virology , biochemistry , virus , nucleotide , mathematics , gene
9-[2-(phosphonomethoxy)ethyl]guanine (PMEG) is one of the most active antiproliferative compounds in a series of acyclic nucleoside phosphonates and is active in intraperitoneal P388 tumors in mice.
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