Sympathetic Modulation of the Host Defense Response to Infectious Challenge during Recovery from Hemorrhage | Zendy

Annie M. Whitaker | Zendy; Fuhong Su | Zendy; Edith Walker | Zendy; Keisa W. Mathis | Zendy; Patricia E. Molina | Zendy

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Sympathetic Modulation of the Host Defense Response to Infectious Challenge during Recovery from Hemorrhage

Author(s) -

Annie M. Whitaker,

Fuhong Su,

Edith Walker,

Keisa W. Mathis,

Patricia E. Molina

Publication year - 2010

Publication title -

neuroimmunomodulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.635

H-Index - 65

eISSN - 1423-0216

pISSN - 1021-7401

DOI - 10.1159/000292039

Subject(s) - medicine , resuscitation , hemodynamics , norepinephrine , hypothermia , anesthesia , blood pressure , sympathectomy , haemodynamic response , inflammatory response , inflammation , heart rate , dopamine

Trauma/hemorrhage (TxHem) is associated with an immediate pro-inflammatory response that, if exaggerated or prolonged, is thought to contribute to the subsequent immunosuppression that characterizes the period after injury. Previously we have demonstrated that chemical sympathectomy (SNSx) accentuates this immediate pro-inflammatory response to TxHem. These findings suggest that the noradrenergic system plays a critical role in limiting the magnitude of the inflammatory response during TxHem and preserving the integrity of the host defense response to a subsequent infectious challenge during the period after TxHem.

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