Serum Levels of Androstenedione, Testosterone and Dehydroepiandrosterone Sulfate in Patients with Premature Ovarian Failure to Age-Matched Menstruating Controls | Zendy

A.N. Elias | Zendy; M.R. Pandian | Zendy; F J Rojas | Zendy

Open Access

Serum Levels of Androstenedione, Testosterone and Dehydroepiandrosterone Sulfate in Patients with Premature Ovarian Failure to Age-Matched Menstruating Controls

Author(s) -

A.N. Elias,

M.R. Pandian,

F J Rojas

Publication year - 1997

Publication title -

gynecologic and obstetric investigation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.631

H-Index - 63

eISSN - 1423-002X

pISSN - 0378-7346

DOI - 10.1159/000291817

Subject(s) - androstenedione , dehydroepiandrosterone sulfate , medicine , dehydroepiandrosterone , endocrinology , androgen , testosterone (patch) , premature ovarian failure , hyperandrogenism , hormone , obesity , polycystic ovary , insulin resistance

Serum concentrations of androstenedione, testosterone and dehydroepiandrosterone sulfate (DHEAS) were measured in 29 patients with premature ovarian failure (POF) and an identical number of age-matched normal control subjects. The study was aimed at determining possible differences in androgen concentrations of ovarian and adrenal origin in POF patients and age-matched normal menstruating controls. Serum testosterone and DHEAS concentrations in the 2 populations were not significantly different. The serum androstenedione concentration in the POF patient group (3,077.50 +/- 1,122.33 pmol/l) was significantly lower than in age-matched normal control subjects (4,167.70 +/- 1,381.09 pmol/l, p < 0.005), possibly reflecting the loss of ovarian androstenedione secretion and/or a subtle defect in adrenal steroidogenic capacity.

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