Open AccessC-Peptide as a Therapeutic Tool in Diabetic Nephropathy
Author(s) -
Claire E. Hills,
Nigel J. Brunskill,
Paul E. Squires
Publication year - 2010
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000289864
Subject(s) - diabetic nephropathy , medicine , endocrinology , microalbuminuria , nephropathy , peptide , glomerular hyperfiltration , diabetes mellitus , biochemistry , biology
Insulin is synthesised as a pro-hormone with an interconnecting C-peptide, cleaved during post-translational modification. This review discusses growing evidence which indicates that C-peptide is biologically active, benefiting microvascular complications associated with diabetes.
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