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Fatty acid-bearing albumin [FA(+) albumin] exerts more deleterious effects in tubular cells than albumin alone. We investigated the effect of FA(+) albumin on the vascular cell adhesion molecule-1 (VCAM-1) expression and elucidated the underlying signaling pathways. We further examined the effect of L-carnitine, since it was known to modulate intracellular fatty acid concentration.

Fatty Acid-Bearing Albumin Induces VCAM-1 Expression through c-Src Kinase-AP-1/NF-ĸB Pathways: Effect of <i>L</i>-Carnitine