Fatty Acid-Bearing Albumin Induces VCAM-1 Expression through c-Src Kinase-AP-1/NF-ĸB Pathways: Effect of L-Carnitine | Zendy

Joo Eun Baek | Zendy; Won Suk Yang | Zendy; Jai Won Chang | Zendy; Soon Bae Kim | Zendy; Su Kil Park | Zendy; Jung Sik Park | Zendy; Sang Koo Lee | Zendy

Open Access

Fatty Acid-Bearing Albumin Induces VCAM-1 Expression through c-Src Kinase-AP-1/NF-ĸB Pathways: Effect of <i>L</i>-Carnitine

Author(s) -

Joo Eun Baek,

Won Suk Yang,

Jai Won Chang,

Soon Bae Kim,

Su Kil Park,

Jung Sik Park,

Sang Koo Lee

Publication year - 2010

Publication title -

kidney and blood pressure research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.806

H-Index - 51

eISSN - 1423-0143

pISSN - 1420-4096

DOI - 10.1159/000289576

Subject(s) - microbiology and biotechnology , kinase , tyrosine kinase , chemistry , proto oncogene tyrosine protein kinase src , protein kinase a , signal transduction , biochemistry , biology

Fatty acid-bearing albumin [FA(+) albumin] exerts more deleterious effects in tubular cells than albumin alone. We investigated the effect of FA(+) albumin on the vascular cell adhesion molecule-1 (VCAM-1) expression and elucidated the underlying signaling pathways. We further examined the effect of L-carnitine, since it was known to modulate intracellular fatty acid concentration.

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