Leucine-Rich Repeat Kinase 2 Gene-Associated Disease: Redefining Genotype-Phenotype Correlation | Zendy

Christian Wider | Zendy; Dennis W. Dickson | Zendy; Zbigniew K. Wszołek | Zendy

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Leucine-Rich Repeat Kinase 2 Gene-Associated Disease: Redefining Genotype-Phenotype Correlation

Author(s) -

Christian Wider,

Dennis W. Dickson,

Zbigniew K. Wszołek

Publication year - 2010

Publication title -

neurodegenerative diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.98

H-Index - 57

eISSN - 1660-2862

pISSN - 1660-2854

DOI - 10.1159/000289232

Subject(s) - progressive supranuclear palsy , lrrk2 , frontotemporal dementia , dementia with lewy bodies , parkinsonism , neurodegeneration , pathology , dementia , medicine , atrophy , frontotemporal lobar degeneration , parkinson's disease , disease

Leucine-rich repeat kinase 2 (LRRK2) has emerged as the most prevalent genetic cause of Parkinson's disease (PD) among Caucasians. Patients carrying an LRRK2 mutation display significant variability of clinical and pathologic phenotypes across and within affected families.

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