Ovine Proinflammatory Cytokines Cross the Murine Blood-Brain Barrier by a Common Saturable Transport Mechanism | Zendy

Steven W. Threlkeld | Zendy; Jessica Lynch | Zendy; Kristin M. Lynch | Zendy; Grazyna B. Sadowska | Zendy; William A. Banks | Zendy; Barbara S. Stonestreet | Zendy

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Ovine Proinflammatory Cytokines Cross the Murine Blood-Brain Barrier by a Common Saturable Transport Mechanism

Author(s) -

Steven W. Threlkeld,

Jessica Lynch,

Kristin M. Lynch,

Grazyna B. Sadowska,

William A. Banks,

Barbara S. Stonestreet

Publication year - 2010

Publication title -

neuroimmunomodulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.635

H-Index - 65

eISSN - 1423-0216

pISSN - 1021-7401

DOI - 10.1159/000288265

Subject(s) - proinflammatory cytokine , blood–brain barrier , cytokine , chemistry , medicine , endocrinology , microbiology and biotechnology , biology , inflammation , immunology , central nervous system

The cytokines interleukin (IL)-1beta and IL-6 are modulators of the neuroimmune axis and have been implicated in neuronal cell death cascades after ischemia or infection. Previous work has shown that some cross-species conservation exists between human and rodent blood-brain barrier (BBB) transport systems. To further assess cross-species conservation of cytokine transport across the BBB, the current studies investigated permeability and inhibition of ovine IL-1beta and IL-6 in the mouse.

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