Genetic Predisposition to Advanced Glycation End Products Toxicity Is Related to Prognosis of Chronic Hemodialysis Patients | Zendy

Marta Kalousová | Zendy; Marie Jáchymová | Zendy; Alexandra Germanová | Zendy; Aleš Kuběna | Zendy; Vladimı́r Tesař | Zendy; Tomáš Zima | Zendy

Open Access

Genetic Predisposition to Advanced Glycation End Products Toxicity Is Related to Prognosis of Chronic Hemodialysis Patients

Author(s) -

Marta Kalousová,

Marie Jáchymová,

Alexandra Germanová,

Aleš Kuběna,

Vladimı́r Tesař,

Tomáš Zima

Publication year - 2010

Publication title -

kidney and blood pressure research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.806

H-Index - 51

eISSN - 1423-0143

pISSN - 1420-4096

DOI - 10.1159/000285845

Subject(s) - glycation , rage (emotion) , medicine , hazard ratio , hemodialysis , gastroenterology , proportional hazards model , endocrinology , receptor , immunology , biology , confidence interval , neuroscience

Advanced glycation end products (AGEs) belong to uremic toxins and some pathological effects of AGEs are linked to RAGE (receptor for AGEs). Their precursors are detoxified by the glyoxalase (GLO) system. The A419C (E111A) polymorphism of the GLO I gene is associated with vascular disease in hemodialysis (HD) patients and some RAGE gene polymorphisms are implicated in various pathological states.

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