Novel Adenovirus Vectors ‘Capsid-Displaying’ a Human Complement Inhibitor | Zendy

Sergey S. Seregin | Zendy; Zachary C. Hartman | Zendy; Daniel M. Appledorn | Zendy; Sarah Godbehere | Zendy; Haixiang Jiang | Zendy; Michael M. Frank | Zendy; Andrea Amalfitano | Zendy

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Novel Adenovirus Vectors ‘Capsid-Displaying’ a Human Complement Inhibitor

Author(s) -

Sergey S. Seregin,

Zachary C. Hartman,

Daniel M. Appledorn,

Sarah Godbehere,

Haixiang Jiang,

Michael M. Frank,

Andrea Amalfitano

Publication year - 2010

Publication title -

journal of innate immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.078

H-Index - 64

eISSN - 1662-8128

pISSN - 1662-811X

DOI - 10.1159/000284368

Subject(s) - capsid , complement system , complement (music) , computational biology , genetic enhancement , biology , innate immune system , viral vector , gene transfer , microbiology and biotechnology , fusion protein , virology , gene , immunology , virus , genetics , antibody , receptor , recombinant dna , complementation , phenotype

Adenovirus (Ad) vectors are currently the most commonly utilized gene transfer vectors in humans worldwide. Unfortunately, upon contact with the circulatory system, Ads induce several, innate, complement-dependent toxicities that limit the full potential for Ad-based gene transfer applications. Therefore, we have constructed several novel Ad5-based vectors, 'capsid-displaying' as fiber or pIX fusion proteins, a complement-regulatory peptide (COMPinh). These novel Ads dramatically minimize Ad-dependent activation of the human and non-human primate complement systems, as determined by several assays. In summary, our work has shown that a novel COMPinh-displaying Ad5 has the potential for broadening the safe use of Ad vectors in future human applications.

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