GH/IGF-I Regulation in Obesity – Mechanisms and Practical Consequences in Children and Adults | Zendy

Ilonka KreitschmannAndermahr | Zendy; Pablo Suarez | Zendy; Rachel Jennings | Zendy; Nina Evers | Zendy; Georg Brabant | Zendy

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GH/IGF-I Regulation in Obesity – Mechanisms and Practical Consequences in Children and Adults

Author(s) -

Ilonka KreitschmannAndermahr,

Pablo Suarez,

Rachel Jennings,

Nina Evers,

Georg Brabant

Publication year - 2010

Publication title -

hormone research in paediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.816

H-Index - 89

eISSN - 1663-2826

pISSN - 1663-2818

DOI - 10.1159/000284355

Subject(s) - obesity , endocrinology , overweight , medicine , growth hormone , secretion , hormone , growth hormone deficiency

Growth hormone (GH) secretion in children and adults is profoundly, but reversibly, suppressed in obesity. Since GH deficiency leads to increased fat mass, differentiation of both conditions remains challenging. Here we review the known and still speculative mechanisms underlying the inhibitory effects of obesity on GH secretion including peripheral factors like IGF-I and insulin, as well as central hypothalamic/pituitary modulators. We further discuss the basis of current testing for GH deficiency in obesity and the validity of the various provocative tests in overweight subjects.

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