The T Cell Response to Major Grass Allergens Is Regulated and Includes IL-10 Production in Atopic but Not in Non-Atopic Subjects | Zendy

A. Domdey | Zendy; A. Liu | Zendy; Anders Millner | Zendy; Kaare Lund | Zendy; H. Jacobi | Zendy; H.J. Malling | Zendy; I. Søndergaard | Zendy; Peter Adler Würtzen | Zendy

Open Access

The T Cell Response to Major Grass Allergens Is Regulated and Includes IL-10 Production in Atopic but Not in Non-Atopic Subjects

Author(s) -

A. Domdey,

A. Liu,

Anders Millner,

Kaare Lund,

H. Jacobi,

H.J. Malling,

I. Søndergaard,

Peter Adler Würtzen

Publication year - 2010

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000283033

Subject(s) - immunology , il 2 receptor , cytokine , peripheral blood mononuclear cell , chemokine , medicine , allergy , allergic inflammation , t cell , biology , immune system , in vitro , biochemistry

The incidence of allergic diseases is increasing in industrialized countries and the immunological mechanisms leading to tolerance or allergy are poorly understood. Cytokines with suppressive abilities and CD4(+)CD25(+) regulatory T cells have been suggested to play a central role in allergen-specific responses. The aim was to determine whether major grass allergens induce production of suppressive cytokines in allergic and healthy subjects and to examine the inhibitory effect of these cytokines on allergic responses.

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