Negative Regulation of the Tight Junction Protein Tricellulin by Snail-Induced Epithelial-Mesenchymal Transition in Gastric Carcinoma Cells
Author(s) -
Risayo Masuda,
Shuho Semba,
Eri Mizuuchi,
Kazuyoshi Yanagihara,
Hiroshi Yokozaki
Publication year - 2010
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000278293
Subject(s) - vimentin , epithelial–mesenchymal transition , transcription factor , microbiology and biotechnology , biology , chemistry , immunohistochemistry , downregulation and upregulation , immunology , gene , biochemistry
Tricellulin plays a central role in the sealing of epithelia at tricellular contacts. We examined the effects of Snail, an epithelial-mesenchymal transition (EMT)-related transcription factor, on the regulation of tricellulin expression in human gastric carcinoma (GC)-derived cells.
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