RNA Interference in Ageing Research – A Mini-Review | Zendy

Nadège Minois | Zendy; Peter Sykacek | Zendy; Brian Godsey | Zendy; David P. Kreil | Zendy

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RNA Interference in Ageing Research – A Mini-Review

Author(s) -

Nadège Minois,

Peter Sykacek,

Brian Godsey,

David P. Kreil

Publication year - 2010

Publication title -

gerontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.397

H-Index - 94

eISSN - 1423-0003

pISSN - 0304-324X

DOI - 10.1159/000277626

Subject(s) - rna interference , drosophila melanogaster , biology , caenorhabditis elegans , computational biology , model organism , gene silencing , genome , gene , ageing , genetics , functional genomics , genomics , rna

The search for genetic mechanisms affecting life-span and ageing represents an important part of ageing research, especially since the discovery of single-gene mutations with dramatic effects on these traits. Due to its relative ease of use and its power to specifically target arbitrary genes, RNA interference (RNAi) has rapidly been adopted as a technique for silencing gene expression. The feasibility of genome-wide RNAi screens potentially much simplifies the identification of novel ageing-related genes.

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