Evaluation of Transforming Growth Factor-β Signaling Pathway in the Wall of Normal and Varicose Veins | Zendy

Radosław Kowalewski | Zendy; Andrzej Małkowski | Zendy; Krzysztof Sobolewski | Zendy; M Gacko | Zendy

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Evaluation of Transforming Growth Factor-β Signaling Pathway in the Wall of Normal and Varicose Veins

Author(s) -

Radosław Kowalewski,

Andrzej Małkowski,

Krzysztof Sobolewski,

M Gacko

Publication year - 2010

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000272948

Subject(s) - varicose veins , pathogenesis , extracellular matrix , transforming growth factor , medicine , receptor , signal transduction , vein , messenger rna , endocrinology , biology , microbiology and biotechnology , surgery , gene , biochemistry

Extracellular matrix remodeling in the vein wall is involved in varicose vein pathogenesis, with transforming growth factor beta(1) (TGF-beta(1)) playing a potential role. The aim of the study was to assess the TGF-beta signaling pathway including its receptor (TGF-beta RII) and phosphorylated receptor-regulated Smads (p-Smad2/3) in varicose veins.

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