Porphyromonas gingivalis Antigens and Interleukin-6 Stimulate the Production of Monocyte Chemoattractant Protein-1 via the Upregulation of Early Growth Response-1 Transcription in Human Coronary Artery Endothelial Cells | Zendy

Tomoki Maekawa | Zendy; Naoki Takahashi | Zendy; Tomoyuki Honda | Zendy; Daisuke Yonezawa | Zendy; Hirotaka Miyashita | Zendy; Takafumi Okui | Zendy; Koichi Tabeta | Zendy; Kazuhisa Yamazaki | Zendy

Open Access

<i>Porphyromonas gingivalis</i> Antigens and Interleukin-6 Stimulate the Production of Monocyte Chemoattractant Protein-1 via the Upregulation of Early Growth Response-1 Transcription in Human Coronary Artery Endothelial Cells

Author(s) -

Tomoki Maekawa,

Naoki Takahashi,

Tomoyuki Honda,

Daisuke Yonezawa,

Hirotaka Miyashita,

Takafumi Okui,

Koichi Tabeta,

Kazuhisa Yamazaki

Publication year - 2009

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000265568

Subject(s) - porphyromonas gingivalis , downregulation and upregulation , monocyte , biology , chemotaxis , immunology , microbiology and biotechnology , endocrinology , medicine , periodontitis , receptor , biochemistry , gene

Individuals with periodontitis have elevated serum levels of IL-6 and C-reactive protein and have been reported to have a significantly increased risk of developing cardiovascular disease. The transcription factor early growth response factor 1 (Egr-1) has been shown to play an important role in the development and progression of atherosclerosis. However, it is not known whether periodontal infection affects the expression of Egr-1 and subsequent endothelial cells expression of monocyte chemoattractant protein (MCP)-1, a key molecule of leukocyte chemoattraction into vessels.

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