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Angiogenesis is a feature of the atherogenic process, with intimal neovascularisation arising from vessels in the adventitia, adjacent to a plaque. Immature, leaky blood vessels from unstable plaques proliferate abnormally and, being poorly invested with smooth muscle cells, may contribute to instability of the plaque by facilitation of inflammatory cell infiltration and haemorrhagic complications.

Identification of a ‘Snapshot’ of Co-Expressed Angiogenic Markers in Laser-Dissected Vessels from Unstable Carotid Plaques with Targeted Arrays