Open AccessSenescence of Cultured Porcine Coronary Arterial Endothelial Cells Is Associated with Accelerated Oxidative Stress and Activation of NFĸB
Author(s) -
Mary Y. K. Lee,
Yu Wang,
Paul M. Vanhoutte
Publication year - 2009
Publication title -
journal of vascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 74
eISSN - 1423-0135
pISSN - 1018-1172
DOI - 10.1159/000265563
Subject(s) - oxidative stress , senescence , endothelial dysfunction , biology , microbiology and biotechnology , apoptosis , superoxide dismutase , endothelium , signal transduction , chemistry , endocrinology , biochemistry
Endothelial dysfunction occurs following multiple passaging in vitro,but the molecular mechanisms involved remain unidentified. The present study defined the genomic changes related to dysfunction in cultured senescent endothelial cells.
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