A Toll-Like Receptor 2/6 Agonist Reduces Allergic Airway Inflammation in Chronic Respiratory Sensitisation to Timothy Grass Pollen Antigens | Zendy

Barbara Fuchs | Zendy; S. Knothe | Zendy; Sabine Rochlitzer | Zendy; Matthias Nassimi | Zendy; Marina Greweling | Zendy; Hans-Dieter Lauenstein | Zendy; Christissenstein | Zendy; Meike Müller | Zendy; Thomas Ebensen | Zendy; AnnaMaria Dittrich | Zendy; Norbert Krug | Zendy; Carlos A. Guzmán | Zendy; Armin Braun | Zendy

Open Access

A Toll-Like Receptor 2/6 Agonist Reduces Allergic Airway Inflammation in Chronic Respiratory Sensitisation to Timothy Grass Pollen Antigens

Author(s) -

Barbara Fuchs,

S. Knothe,

Sabine Rochlitzer,

Matthias Nassimi,

Marina Greweling,

Hans-Dieter Lauenstein,

Christissenstein,

Meike Müller,

Thomas Ebensen,

AnnaMaria Dittrich,

Norbert Krug,

Carlos A. Guzmán,

Armin Braun

Publication year - 2009

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000265534

Subject(s) - immunology , tlr2 , medicine , immune system , inflammation , allergic inflammation , toll like receptor , foxp3 , agonist , allergy , nasal administration , innate immune system , receptor

The hygiene hypothesis negatively correlates the microbial burden of the environment with the prevalence of T helper type 2 (Th2)-related disorders, e.g. allergy and asthma. This is explained by Th1 triggering through pathogen-associated molecular patterns via Toll-like receptors (TLRs). In this study, the biological effects of a TLR2/6 agonist as a potential treatment of allergic inflammation are explored.

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