Deficient Histone Acetylation in Acute Leukemia and the Correction by an Isothiocyanate | Zendy

Liyun Xiao | Zendy; Yiqun Huang | Zendy; Ruiji Zhen | Zendy; Jen-Wei Chiao | Zendy; Delong Liu | Zendy; Xudong Ma | Zendy

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Deficient Histone Acetylation in Acute Leukemia and the Correction by an Isothiocyanate

Author(s) -

Liyun Xiao,

Yiqun Huang,

Ruiji Zhen,

Jen-Wei Chiao,

Delong Liu,

Xudong Ma

Publication year - 2009

Publication title -

acta haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 56

eISSN - 1421-9662

pISSN - 0001-5792

DOI - 10.1159/000264628

Subject(s) - acetylation , histone , hdac8 , leukemia , cancer research , epigenetics , acute leukemia , hdac11 , myeloid leukemia , histone deacetylase 2 , isothiocyanate , histone h3 , histone h4 , microbiology and biotechnology , biology , histone deacetylase , histone methyltransferase , immunology , biochemistry , gene

Since histone hypoacetylation due to excess histone deacetylases (HDACs) has been associated with transcriptional repression in leukemia, we aimed to determine deficient histone acetylation in patients with acute leukemia and the effect of its correction by an isothiocyanate.

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