Allelic Heterogeneity in Genetic Association Meta-Analysis: An Application to DTNBP1 and Schizophrenia | Zendy

Brion S. Maher | Zendy; Mark A. Reimers | Zendy; Brien P. Riley | Zendy; Kenneth S. Kendler | Zendy

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Allelic Heterogeneity in Genetic Association Meta-Analysis: An Application to <i>DTNBP1</i> and Schizophrenia

Author(s) -

Brion S. Maher,

Mark A. Reimers,

Brien P. Riley,

Kenneth S. Kendler

Publication year - 2009

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000264445

Subject(s) - genetic association , allelic heterogeneity , biology , single nucleotide polymorphism , meta analysis , genetics , allele , genetic heterogeneity , genome wide association study , snp , locus (genetics) , computational biology , genotype , gene , phenotype , medicine

Meta-analysis of genetic association studies is a useful approach when individual investigations do not yield studywise significant results but the evidence across studies is modest and homogeneous. Current meta-analysis methods account for heterogeneity by down-weighting studies as a function of between-study variance. We contend that current approaches may obscure interesting phenomena in genetic association data. However, an appropriate approach to examining heterogeneity across studies is lacking.

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