Open AccessMelanocortins Mimic the Effects of Leptin to Restore Reproductive Function in Lean Hypogonadotropic Ewes
Author(s) -
Kathryn Backholer,
Marissa A. Bowden,
Kevin Gamber,
Christian Bjørbæk,
Javed Iqbal,
Iain J. Clarke
Publication year - 2009
Publication title -
neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.493
H-Index - 101
eISSN - 1423-0194
pISSN - 0028-3835
DOI - 10.1159/000260060
Subject(s) - endocrinology , medicine , proopiomelanocortin , melanocortin , leptin , hypothalamus , biology , arc (geometry) , appetite , melanocortin receptor , chemistry , hormone , obesity , geometry , mathematics
Leptin restores gonadotropic function in lean hypogonadotropic animals by an unknown mechanism. We aimed to test the hypothesis that restoration of gonadotropic function is a result of an upregulation of central acetylated melanocortin production.
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